By Karsten Schrör
Written via a number one specialist on Aspirin-related examine, this can be the main finished treatise at the pharmacological results and scientific functions of 1 of the main winning medications ever.
The textual content is written with a large viewers in brain, and to be without problems comprehensible for clinicians, pharmacists, biomedical researchers and pharmacologists alike.
This moment, thoroughly revised version comprises the newest result of medical and pharmacological learn on Acetylsalicylic acid, addressing the a number of pharmacological homes of this recognized drug with a balanced view on their translation into medical perform, together with prevention from cardiovascular ailments and colorectal cancer.
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Extra resources for Acetylsalicylic Acid
Die Pharmazie, 4, 582–584. € ber Aspirin 16 Dreser, H. (1899) Pharmakologisches u (Acetylsalizyls€aure). Pﬂ€ ugers Archiv. European Journal of Physiology, 76, 306–318. I. and Scheidt, S. (1994) History of drugs for thrombotic diseases. Discovery, development and directions for the future. Circulation, 89, 432–449. 18 Sneader, W. (2000) The discovery of aspirin: a reappraisal. British Medical Journal, 321, 1591–1594. F. (1855) Lehrbuch der Organischen Chemie. Deutsche Originalausgabe unter Mitwirkung von Prof.
8) but not with its m- and p-analogues. The o-position of the hydroxyl group facilitates the release of a proton with decreasing pH by increasing the mesomery of the resulting anion. 3). 1). The m- and p-hydroxy analogues of benzoic acid do not share these properties with salicylate and are biologically largely inactive. Structure–activity studies of 80 salicylate-type compounds for uncoupling oxidative phosphorylation in isolated mitochondria showed that the essential pharmacophore for this activity is a compound with a negatively charged (carboxyl) group at the o-position, that is, acetylsalicylate.
The FASEB Journal, 5, 2304–2312. J. M. (1979) Effect of aspirin on incidence of preeclampsia. The Lancet, 1, 1356. , Donsimoni, R. C. (1985) Prevention of preeclampsia by early antiplatelet therapy. The Lancet, 1, 840–842. C. (1949) Aspirin in the treatment of vascular diseases. The Lancet, 2, 1172–1174. L. (1950) Acetylsalicylic acid, possible prevention of coronary thrombosis. Annals of Western Medicine and Surgery, 4, 95–99. 55 Miner, J. and Hoffhines, A. (2007) The discovery of aspirins antithrombotic effects.
Acetylsalicylic Acid by Karsten Schrör