By Frank J. Dixon (Ed.)
With contributions from Steven A. Porcelli and different the world over famous leaders within the box, this quantity keeps the culture of quintessential studies. Papers at the CD1 kinfolk, confident collection of thymocytes, and molecular and mobile features of XLA spotlight the newest quantity.
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Additional info for Advances in Immunology, Vol. 59
Thus, it is unclear which form(s) of CD1 are recognized by these mAbs, although it is likely that the sheep and bovine mAbs recognize group 1 C D l proteins based on the patterns observed in tissue staining. No antibodies against CD1 molecules of birds or other nonmammalian species have yet been described. V. Biochemical and lmmunochemical Studies of CDl Proteins The availability of monoclonal antibodies against CD1 antigens has facilitated direct biochemical analyses of these proteins. Such studies were responsible for the initial recognition of the structural relationship between CD1 and MHC class I proteins, since they revealed the distinctive heavy-chain plus p2-microglobulin subunit structure of both types of proteins.
This analysis is summarized in Fig. 10. Note that CD1 proteins contain more hydrophobic regions in their a1 and a 2 domains than do MHC class I or I1 molecules, and that index of hydrophobicity is generally greater in such regions in CD1 proteins. , 1990). The hydrophobicity of CD1 proteins is particularly pronounced on the a 2 domain, especially in C D l b and -c. This feature of CD1 proteins could indicate the ability to form a binding site for hydrophobic ligands. As discussed later (see Section VI), this would fit well with current proposals for how CD1 functions in antigen presentation.
References for individual sequences are given in the text. , 1989c, 1991). As a further illustration of this important point, a phylogenetic tree based on the membrane proximal domain sequences of CD1, MHC class I and 11, and MHC-related molecules is shown in Fig. 7. On the basis of this evolutionary scheme, it seems reasonable to consider the possibility that CD1 could represent a family of antigen-presenting molecules that has evolved to perform a function that is distinct and complementary to that performed by MHC class I and 11.
Advances in Immunology, Vol. 59 by Frank J. Dixon (Ed.)