Read e-book online Advances in Mercury Toxicology PDF

By Tsuguyoshi Suzuki, Nobumasa Imura, Thomas W. Clarkson

ISBN-10: 1475790716

ISBN-13: 9781475790719

ISBN-10: 1475790732

ISBN-13: 9781475790733

This ebook relies on a global assembly equipped through the college of Tokyo and the college of Rochester, and is released as one belonging to the sequence of Rochester foreign meetings in Environmental Toxicity. The assembly on "Advances in Mercury Toxicology" was once held on the college of Tokyo on August 1 to three, 1990. The invited papers are released during this booklet besides an "Overview" bankruptcy that was once written by means of the editors at a gathering held on the collage of Rochester on August 1 to two, 1991. the aim of the assembly used to be to collect prime scientists to debate their most modern findings at the toxicology of mercury. The time used to be opportune. huge development has been made at the environmental destiny and toxicology of mercury. fresh findings have given new perception into the worldwide version for mercury. delivery within the surroundings extends nice distances leading to pollutants of lakes and rivers some distance far-off from the resource of mercury unencumber. the method of methylation results in accumulation of methylmercury in fish and hence within the human nutrition. New facts exhibits that acid rain and the impoundment of water for hydroelectric reasons impacts the methylation and bioaccumulation procedures leading to larger degrees of methylmercury in fish.

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Polygraphic (EEG, EMG, ECG and temperature recording with thermister) observations were conducted on rats administered orally with MeHg (Arito and Takahashi). The maximum brain mercury concentration of 10 jlg/g was associated with the marked changes in sleep-wakefulness pattern and body temperature change, while this change in the vigilance state started to occur at concentrations of 1-3 jlg/g. In accordance with this sleep-wakefulness change, the levels of 5-hydroxytryptamine, noradrenalin and 3-methoxy-4-hydroxy-phenylethyleneglycol in the frontal cortex were decreased during the dark period, indicating the lowered turnover of central monoamine metabolism due to MeHg.

24 Overview Behavioral Teratology Recent epidemiological studies in Iraq, Canada and New Zealand have suggested that in utero exposure to MeHg at lower doses than those toxic to adults may induce minor abnormalities which are only detectable by psychological and behavioral tests in the offspring. A need for further epidemiological studies to define the minimum toxic dose of MeHg for the human embryo and fetus has been commonly recognized. In connection with this problem, experimental behavioral teratology has come to fore again, since it has been known to have the most sensitivity to the abnormalities (see chapter by Satoh).

In Minamata, the brains of affected babies showed disorganization of the cerebral cortical architecture with 23 T. Suzuki et al. degeneration of nerve cells and decrease in their number: the changes are basically similar to those found in adult Minamata disease sufferers (Inoue). As Choi pointed out in the conference, taking the complexity of brain development into account, precise information regarding the location and timing of insults in relation to ontogenic events is absolutely necessary when studying the effects of MeHg.

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Advances in Mercury Toxicology by Tsuguyoshi Suzuki, Nobumasa Imura, Thomas W. Clarkson


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