By Joseph W. St. Geme III
This publication describes the growing to be physique of data at the epidemiology, medical manifestations, transmission, pathogenesis, analysis, and remedy of Kingella kingae infectionsin little ones. additionally, it covers experimental equipment which were constructed to check the microbiology, genetics, and virulence elements of K. kingae, info that offers the root for brand spanking new techniques to therapy and prevention of K. kingae disease. With this content material in brain, excerpts from the booklet could be of relevance for clinicians who deal with pediatric sufferers, for medical microbiologists who're interested in detecting organisms in scientific specimens, and for scientists who're learning K. kingae in an attempt to enhance novel ambitions for antimicrobial remedy and new methods to prevention.
First remoted within the Nineteen Sixties through Elizabeth O. King, a bacteriologist on the CDC, Kingella kingae was once principally overlooked over the following twenty years as a human pathogen as a result of its unusual restoration from sufferers with illness. in spite of the fact that, lately K. kingae has been more and more well-known as a clinically vital pathogen in little ones, and is at the moment famous because the top reason behind osteoarticular infections in kids in progressively more international locations. study into this organism has grown drastically over the last 15 years, leading to a greater appreciation of the significance of K. kingae in pediatric sufferers and of the molecular mechanisms of disorder.
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Extra info for Advances in Understanding Kingella kingae
Kingae disease. The time to medical care is often delayed because of the relatively indolent nature of K. kingae disease, but outcomes are generally favorable. K. kingae endocarditis is a rare but signiﬁcant infection in patients of all ages and tends to be associated with poor outcomes and signiﬁcant complications in children. References 1. Yagupsky P (2015) Kingella kingae: carriage, transmission, and disease. Clin Microbiol Rev 28(1):54–79. 00028-14 2. Yagupsky P, Greenberg D (2012) Kingella species.
Kingae disease in healthy individuals, Slonim et al.  examined serum IgA and IgG levels against outer membrane proteins in 19 children with invasive disease. As expected, there were signiﬁcant increases in serum IgA and IgG levels in children convalescing from invasive disease. Further study revealed that the age incidence of disease is inversely correlated with serum IgA and IgG levels in healthy individuals. Infants younger than 6 months of age have undetectable levels of IgA but high levels of serum IgG, suggesting that protection from invasive disease in this age group is due to maternally derived IgG .
Geme, submitted). In the Israeli collection of isolates, approximately 96 % of invasive disease isolates expressed either the type a or type b capsule. In contrast, only 70 % of carrier isolates expressed the type a or type b capsule, suggesting that the type a and type b capsule structures may provide a selective advantage for the organism in the bloodstream and contribute to the development of K. kingae invasive disease (Starr, Porsch, and St. Geme, submitted). Given that these initial studies focused on Israeli clinical isolates, further research is necessary to determine the global distribution of K.
Advances in Understanding Kingella kingae by Joseph W. St. Geme III