By Craig Niederberger
An creation to Male Reproductive drugs is written particularly for readers looking access into this fast-moving, advanced area of expertise with a great knowing of the topic. the 1st chapters hide the anatomy and body structure, medical assessment, surgical procedure, medication, genetics and laboratory trying out excited about the present evaluate and remedy of the infertile male, and the ultimate bankruptcy describes the interplay of the sector with woman reproductive drugs. through the booklet, references are without delay made to the fourth variation of the key textual content within the distinctiveness, Infertility within the Male, edited via Larry Lipshultz, Stuart Howards and Craig Niederberger, permitting readers to extend their knowing of particular parts the place wanted. every one bankruptcy is written by way of a well-renowned professional in a simple to keep on with, casual kind, making the textual content excellent for college kids, citizens and common physicians who're trying to raise their normal wisdom of the sector.
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Patients understand that radiation damages DNA, and often inquire how long after radiation and chemotherapy is it “safe” for the sperm to impregnate an egg. At this point in medical history, we do not yet know. 1 Typical recovery times for spermatogenesis after radiation Radiation dose (rads) Time until recovery of spermatogenesis 100–200 200–300 400–600 >600 9–12 months 30 months >5 years Permanent sterility Androlog suggested that 2 years might be a reasonable amount of time for a man to wait should sperm return to the ejaculate .
Men may be exposed to toxins such as heavy metals in their workplaces, and asking your patient about his occupation and the chemicals with which he works can be revealing. History of infectious disease The “I” in “TICS” stands for infectious disease. Mumps may land in the testis, and if it does, a man is unlikely to forget the week both his cheeks and scrotum were painfully swollen. Urinary tract infections and sexually transmitted diseases may cause strictures in the lower urinary tract and epididymal obstruction.
Either shorter or longer repeat lengths can result in a relevant biologic effect during a lifetime: shortening of the (CAG)nCAA repeat length was found to correlate with an earlier age of onset of prostate cancer, and a higher tumor grade and aggressiveness (but other epidemiologic studies in prostate cancer patients did not confirm this association), while longer (CAG)nCAA repeats may be associated with defective spermatogenesis. Upon entry of testosterone into the androgen target cell, binding occurs to AR either directly or after its conversion to 5a-dihydrotestosterone.
An Introduction to Male Reproductive Medicine by Craig Niederberger