By Philip M. Parker
In March 2001, the nationwide Institutes of overall healthiness issued the next caution: "The variety of websites providing health-related assets grows on a daily basis. Many websites offer helpful details, whereas others could have details that's unreliable or misleading." moreover, as a result fast raise in Internet-based info, many hours might be wasted looking out, deciding upon, and printing. for the reason that simply the smallest fraction of knowledge facing Prion ailment is listed in se's, comparable to www.google.com or others, a non-systematic method of web examine may be not just time eating, but additionally incomplete. This booklet used to be created for doctors, scholars, and contributors of most of the people who are looking to behavior scientific study utilizing the main complicated instruments to be had and spending the smallest amount of time doing so.
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Extra info for Prion Disease - A Bibliography and Dictionary for Physicians Patients and Genome Researchers
Associate Professor; None; University of Md Biotechnology Institute 701 E Pratt Street, Suite 200 Baltimore, Md 212023101 Timing: Fiscal Year 2005; Project Start 30-SEP-2003; Project End 31-MAY-2007 Summary: (provided by applicant): Prion protein (PrP) underlies a spectrum of diseases with no established treatment and devastating human and economic consequences. Several unique features separate prion diseases from other neurodegenerative maladies. (i) There is an infectious isoform of the prion protein, PrPSc, that propagates its abnormal conformation in an autocatalytic manner using the normal isoform, PrPC, as a substrate.
Healthy carriers of the relevant mutation (E200K) will be identified (n=50), and will be studied before, as well as after, symptomatic expression. Family members lacking the mutation will serve as controls (n=50). In addition, we will recruit into the study all incident CJD cases in Israel that carry this mutation. We believe we will be able to examine these incident cases within 2 months of onset, and follow them for the duration of the disease. All subjects will have extensive neurological and neuropsychological examinations, as well as MRI, using both traditional structural imaging and newer neuroimaging methods: Diffusion- Weighted Imaging (DWI) and Chemical Shift Imaging (CSI).
Copper binding properties of a mutant of PrPc, known as PG14, will be measured to gain an understanding of the molecular basis behind the PG14-associated heritable form of Creutzfeldt-Jakob disease. Finally, a mouse model of an inheritable disease of copper metabolism (Menkes disease) will be used to determine whether PrPc plays a role in the maintenance of copper homeostasis. ; Associate Professor; Neurology; University of Chicago 5801 S Ellis Ave Chicago, Il 60637 Timing: Fiscal Year 2005; Project Start 15-MAR-2003; Project End 28-FEB-2007 Summary: (provided by applicant): The prion diseases are a family of transmissible neurodegenerative disorders that affect humans and animals.
Prion Disease - A Bibliography and Dictionary for Physicians Patients and Genome Researchers by Philip M. Parker